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Contraindications include active or recent cancer, uncontrolled diabetes, severe diabetic retinopathy, and pregnancy
By inhibiting JAK3, ritlecitinib blocks key cytokines involved in T-cell activation and proliferation, such as IL-15.14In vitro data have demonstrated that ritlecitinib inhibits the cytotoxic function of CD8+ T cells and natural killer (NK) cells, including IFN- production, thereby affecting TCR signaling
100 HolmqvistS.ChutnaO.BoussetL.Aldrin-KirkP.LiW.BjrklundT.et al (2014)
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