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While these signs are less specific than visual indicators, they are worth noting and investigating
Garden-variety high blood pressure that is well-controlled on a single medication does not qualify
Weight loss also accelerates during dose escalations, which means more glycogen mobilization and more bound water loss
A clear research agenda prioritizing graft survival, cardiovascular and kidney outcomes, quality of life, cost-effectiveness, and patient-reported outcomesideally via randomized, multicenter or registry-based pragmatic designswill be critical
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