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Excluded from the analysis were studies that contained duplicated data, studies that specifically examined the impact of bupropion on smoking cessation, studies that provided unclear or ambiguous information, studies that utilized bupropion as an intervention in conjunction with other frequently prescribed medications (excluding naltrexone), studies that employed non-randomized trial designs, studies conducted on animals, studies lacking a control group, as well as reviews and meta-analyses

Mice born with liver-specific deletion of Gclc (using a Gclc f/f Albumin-Cre mouse strain) undergo liver failure and die shortly after birth 30

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