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Nettle is a perennial plant, native to western Asia, now widespread in all temperate regions of the globe, including Italy

Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of K ATP channels

The compound's fatty-acid modification introduces an oxidation-sensitive feature beyond standard peptide-bond hydrolysis pathways, so light protection matters more here than for unmodified peptide compounds

In this study we investigated the target occupancy of the dual agonist SAR425899 at the GLP1R in pancreas and GCGR in liver by Positron Emission Tomography/Computed Tomography (PET/CT)