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Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses
The GWAS meta-analysis results for overall ovarian cancer, as well as subtype-specific GWAS results for EOC from the Ovarian Cancer Association Consortium (OCAC) 4 , were used as outcomes in the MR analyses (Supplementary Data 1)
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