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16 g/d) (Patton, 2010)

Research applications for TB-500 include: Skeletal muscle fiber regeneration Chemotaxis of myoblasts, the precursor cells involved in muscle repair Systemic anti-inflammatory modulation Wound healing across skin and connective tissue Because TB-500 circulates systemically after administration, preclinical models suggest it can reach multiple injury sites at once rather than acting only where it is applied

Current findings related to 13 natural products are summarized in Supplementary Appendix 2

The variants of type I, are characterized by this finding, due to the so severe degree of enzymatic deficiency