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Semaglutide has a longer safety track record, proven cardiovascular benefit data (SELECT trial), and FDA approval for adolescents aged 12+
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Cost comparison Cost remains a key consideration in choosing between these therapies
Long-acting MIC-1/GDF15 molecules to treat obesity: evidence from mice to monkeys
Although they originated as diabetes medications, GLP-1 drugs like Wegovy (semaglutide) and Zepbound (tirzepatide) have proven to be highly effective for weight loss
The first search was conducted on Web of Science with the following key terms: ghrelin OR glp-1 OR glucagone-like*) AND reward* AND (fmri OR mri OR neuroimag* on August 10 th , 2022
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