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Rybelsus is a once-daily oral tablet (3, 7, 14, or 25 mg) approved for type 2 diabetes, cardiovascular risk reduction, and obesity (obesity indication added December 2025)

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aOR 0.43 [95% CI 0.28, 0.64]) [25, 44]

The medication itself is straightforward, a once-weekly subcutaneous injection that targets both GIP and GLP-1 receptors to reduce appetite and improve metabolic function