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Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option

We emphasize anti-inflammatory and low-glycemic approaches to eating, alongside targeted supplementation (such as inositol, vitamin D, and omega-3s)