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Endogenous causes (medical conditions) When B12 is elevated without supplementation , it can indicate that the body is releasing stored B12 from damaged tissues, producing excess B12-binding proteins, or failing to clear B12 normally

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Chakrabarti/Campbell Am J Case Rep 2026

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Youre likely familiar with some of the peptides your body makes, such as insulin, which the pancreas makes to regulate the bodys blood sugar endorphins, which are released by the central nervous system to block pain signals and relieve stress growth hormonereleasing hormone, which triggers the pituitary gland to make and release growth hormone