Fatigue Heart palpitations Pale skin Weight loss Infertility Difficulty in thinking and remembering Numbness and tingling in the hands and feet
The bulk of OA research remains preliminary
The Most Common Vitamin B12 Deficiency Symptoms The following symptoms are particularly common: Disrupted energy metabolism (chronic fatigue and tiredness, difficulty concentrating, muscle weakness) Nerve damage (pain, numbness, tingling, paralysis, coordination problems, memory disorders) Anaemia (poor performance, immunodeficiency) Disruptions to the metabolism of hormones and neurotransmitters (mental/psychological disorders, depressions, psychoses) Digestive disorders (constipation, diarrhoea) Inflammation (mouth, stomach and intestines) A more detailed list of B12 deficiency symptoms is given at the end of this article
NNMT is an enzyme that influences methylation processes and is involved in the regulation of nicotinamide and S-adenosylmethionine (SAM) pools
The overall rate of treatment discontinuation due to adverse events was described as relatively low across published trials