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doi:10.1111/jsr.13990
The endogenous incretin glucagon-like peptide-1 (GLP-1) plays a prominent role in maintaining glucose homeostasis
This study demonstrated the importance of combined GLP-1R and GCGR signalling, as administration of the balanced co-agonist to Glp1r -/- mice led to hyperglycaemia, further demonstrating the necessity of GLP-1R and GCGR co-agonism to minimise this predicted side-effect
While GLP-1 medications themselves do not typically cause significant hypotension directly, several mechanisms may contribute to blood pressure reduction
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