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J Neurology Neurosurg Psychiatry

Since human studies are limited, long-term safety is still being evaluated

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aggression, anger, or violence

Patients were randomized to follow a therapeutic cycle for a total period of eight years: citicoline (1,000 mg/day, by intramuscular injection) or placebo (-blockers alone) for a two-month period followed by a four-month washout period (87)