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To further validate these results, we analysed a subset of genes from the Met deprivation signature, which were among the most highly enriched by GSEA, in reprogramming tissues by quantitative PCR with reverse transcription (RTqPCR)

This less frequent dosing schedule can be more convenient and less disruptive to a patients daily routine

The discussion considers several potential mechanisms for DSIPs observed benefits suggesting DSIP could be associated with the rescuing of neurons in motor cortex and subcortical structures involved in motor control