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"Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes." New England Journal of Medicine

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2 Cumulative event rate of (A) proliferative diabetic retinopathy and (B) composite surgical outcome in patients with type 2 diabetes mellitus taking sodium-glucose cotransporter-2 inhibitor (SGLT2i) versus glucagon-like peptide-1 receptor agonist (GLP1-RA) in the inverse probability of treatment weighting-adjusted cohort

I was hurting, I mean, it hurt

The reaction appears to be rare and, in most cases, resolves on its own within a few weeks, according to a 2025 case report in Cureus