Under hyperglycemic conditions, dysfunction of the mitochondrial electron transport chain (ETC.) leads to excessive ROS production, subsequently inducing oxidative damage, mitochondrial DNA (mtDNA) mutations/leakage, and activation of inflammatory pathways such as the NLR family pyrin domain containing 3 (NLRP3) inflammasome and the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING), thereby exacerbating local and systemic inflammation and hindering wound healing (Wang et al., 2025a
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Up to one-third of GLP-1 patients have reported constipation [7]
Studies show that people taking semaglutide can lose around 15% of their body weight
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