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23 Some of the proteins released from mitochondria into the cytoplasm include apoptosis-inducing factor and endonuclease G, both of which have nuclear localization signals and thus translocate to the nucleus, where the endonuclease cleaves DNA, resulting in DNA fragmentation

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It is estimated that the number of T2D patients will increase from 382 million in 2013 to 592 million by 2035 [3]

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