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For perspective, here is every FDA-approved transdermal patch drug and its molecular weight

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[43] Impaired B 12 absorption can also occur following gastric removal (gastrectomy) or gastric bypass surgery

Despite this progress, translation beyond preclinical systems remains limited by insufficient standardisation of synthesis and purification protocols, significant batch-to-batch variability, and incomplete understanding of pharmacokinetics, long-term toxicity and biodistribution