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Declines with age (50% reduction by age 60)
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Knockdown or inhibition of P300 effectively can downregulate KRT18 expression and alleviate necroptosis (29)
Moreover, NUAK1 inhibition causes tumor ICD through H 2 O 2 /OH accumulation and ER stress, as NRF2, downstream of NUAK1, suppresses antioxidant gene expression [263]
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