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Its medicinal-chemistry program, described in detail by Kruse and colleagues, introduced several deliberate substitutions into the amylin backbone: residues borrowed from rat amylin (which does not readily form fibrils) to blunt the aggregation tendency, an engineered salt bridge to stabilize the central helix, and a C 20 fatty-diacid moiety attached through a linker to promote reversible binding to serum albumin
patients should be counseled to seek immediate medical attention for severe, persistent abdominal pain radiating to the back
Getting the reconstitution and dose right matters, but it is only one piece of the picture
In addition, 24 studies met the criteria for quantitative synthesis (meta-analysis)
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