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In keloids, it disrupts the FOXO4-p53 interaction, inducing apoptosis in senescent fibroblasts and reducing pro-inflammatory and mesenchymal fibroblast subpopulations

A sensible precaution is to patch test a small area first and to stop and seek advice if the skin becomes sore or inflamed

(1) Yu-Xiang Kong, Zhi-Shuai Li, Yuan-Bo Liu, Bo Pan, Xin Fu, Ran Xiao & Li Yan (2025) FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation Communications Biology, 24 February 2025, volume 8, Article number: 299

Its job is to let the good things in (water and nutrients) and keep the bad things out (bacteria, toxins, and undigested food)

Additionally, it was noted that AOD9604 did not compete for the hGH receptor nor did it increase cell proliferation ( Peptides Prefer the Cold In order to reduce peptide breakdown, keep peptides refrigerated at all times but DO NOT FREEZE