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FDX1 and LIAS, two key regulators of cuproptosis, are consistently upregulated in bulk RNA-seq, single-cell RNA sequencing, and spatial transcriptomics analyses in human samples (216)
Hepatitis delta virus (HDV) also induces ROS generation by the expression of NOX1 and 4, cytochrome P450 2E1, and ER oxidoreductin 1 86
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Moreover, the tumor microbiota is positively correlated with mitochondrial metabolic activity [87, 88], forming a microbiotametabolismimmunity axis that underpins a multidimensional resistance network and offers new insights for next-generation tumor microenvironmenttargeted strategies
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