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Similarly, thromboembolic events and cardiovascular toxicity may reflect the combined effects of erythrocytosis, dehydration induced by diuretics, stimulant-related vasoconstriction, and adverse lipid alterations (92, 95)

In conclusion, loss of the BBB integrity, caused by the damage of any of its specific cellular component, leads to its functional failure and in turn to cerebrovascular dysfunction, neuroinflammation and neurodegeneration, contributing also to AD development (Desai et al., 2007

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This is underscored by the evidence showing higher body fat loss, coupled with significant reductions in waist circumference, abdominal fat, and BMI in individuals using Semaglutide

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