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Contradictory to clinical research data confirming benefits of long-term treatment, semaglutide is frequently used for a significantly shorter period of time in clinical practice

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This concern comes from studies in rodents, and its not yet known if the risk is the same for humans

These findings collectively suggested that C3G exerts its regulatory effect on GLP-1 secretion by upregulating PG expression, thereby providing a mechanistic basis for its role in modulating GLP-1 release from intestinal L cells (Fig