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Insulin binds with zinc ions to form hexamers, which allow dense packing of insulin in storage vesicles, protecting it from degradation [50, 562]

Communication by extracellular vesicles: where we are and where we need to go

Observations indicate stimulation of osteogenic processes, including increased osteoblast engagement and improved mineralized matrix formation, contributing to enhanced bone continuity and strength during regeneration

Excess reactive oxygen species (ROS) cannot be controlled by the antioxidant system and, thus, potentially impact male fertility and hamper sperm quality parameters

Galluzzi, L., Buqu, A., Kepp, O., Zitvogel, L