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Thirty-six patients received 0.21.5 g/kg ascorbic acid infusion, in the dose-escalation phase, once daily (days 13) with mFOLFOX6 or FOLFIRI in a 14-day cycle until the MTD was reached

multiple images and fields quantified per individual for histological readouts as described)

Epithalon research, while promising, remains more limited in scope and depth

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A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2