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If the COVID-19 vaccines were the most significant FDA approvals of the 2020s so far, GLP-1 agonists to treat obesity are a strong runner up

An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of phase II and III clinical trials

Those numbers were obtained from controlled research settings with monitored dosing and follow-up, not from every real-world scenario

The short answer is that both medications can produce significant weight loss, but retatrutide appears to lead to greater average weight reduction in clinical studies because it targets three hormone receptors involved in metabolism rather than one

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