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In many ways, microdosing GLP-1s reflects a broader shift away from one-size-fits-all dosing and toward individualized care

As per Bradford Hills criteria 41 , the biological plausibility through GLP-1R expression in the nervous system and temporal consistency in time-to-onset analysis support potential causality, but confounding factors inherent to spontaneous reporting systems preclude definitive conclusions

That's not a formality - it's a clinical safeguard that determines whether a patient receives medication at all, and at what dose

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