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Current prescribing information includes warnings related to elevated IGF-1, glucose intolerance, fluid retention, malignancy risk, hypersensitivity, and injection-site reactions. A complete safety discussion belongs in a separate article, but these limitations are essential when interpreting potential benefits

Science 279 , 17181721 (1998)

[PMID: 3074361] PubMed record related to this compound for laboratory literature review

Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro

It is in Phase 3 investigational trials as a "next generation" weight loss medication with potentially fewer side effects compared to single-receptor predecessors like Semaglutide or dual receptor meds like Tirzepatide