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Patients meeting the inclusion/exclusion criteria were randomized in a 2:1 ratio to receive 2 mg tesamorelin or placebo subcutaneously daily for 26 weeks
Inject in one quadrant per day, moving to the next quadrant the following day
By conducting RNA-seq analysis, SOD activity and malondialdehyde assays in ovaries, as well as ROS staining in oocytes, we revealed that the semaglutide treatment reduced the elevated oxidative stress in ovaries and high ROS levels in oocytes from PPO mice, possibly through activating the PI3K/AKT pathway and improving the state of SOD
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