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doi:10 Holst JJ, Orskov C, Nielsen OV, Schwartz TW

Results: Based on the small intestinal transcriptome of geniposide, a recognized small-molecule GLP-1R agonist, we identified that cinchonine exerted GLP-1R agonist-like effects

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Safety concerns related to long-term nanoparticle exposure, variability in herbal extract composition, and the absence of harmonized regulatory frameworks for herbal nanomedicines represent significant barriers to clinical adoption