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Data from designated brain regions from the cFOS 3D brain imaging study were analysed using one-way ANOVA with Dunnets post hoc multiple-comparison test relative to the vehicle, using a negative binomial generalized linear model to control for Gaussian distribution

Methods Animals Male SpragueDawley rats weighing 220 to 250 g were purchased from Sasco Breeding Laboratories (Omaha, NE)

The balance of baseline characteristics between the two groups was assessed using standardized difference (STD), where an absolute STD value 50%) between groups was compared using the Fine and Gray subdistribution hazard model which considered all-cause death during follow-up as a competing risk

This microenvironment is profoundly immunosuppressive, creating multiple layers of resistance that limit the effectiveness of immunotherapeutic interventions

Medical Records: Pre-treatment health status Diagnosis that led to prescription Documentation of symptoms Diagnostic testing (especially gastric emptying scans) Treatment for complications Hospitalizations and ER visits Current status and ongoing treatment 3