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A pivotal RCT in 116 cannabis-dependent adolescents found that NAC (1,200 mg twice daily) more than doubled the odds of a negative urine cannabinoid test compared to placebo (OR 2.4, 95% CI 1.1-5.2) (Gray et al., Am J Psychiatry, 2012) [76]
The main limitation is product claims
In addition, phosphodiesterase-5 inhibitors (PDE-5i), popular among AAS users, were excluded, although they were thought to increase libido after AAS cessation
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