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3 Endocrinology / Metabolism ReviewIGF-1 receptor signalling, insulin-like metabolic effects and glucose handling

It has lubricating and tissue-repair properties

Second, mouse strains expressing disease-causing VCP mutants and those lacking ULK1/2 expression in muscle both develop a vacuolar myopathy with ubiquitin+/SQSTM1+/TDP43+ inclusions, similar to that observed in patients with IBM ( 33 , 35 37 )

May be especially beneficial in patients who are detoxing heavy metals

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