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*Correspondence: Jing-Dong Xu, [email protected] This article was submitted to Gut Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Studies that combined two or more antioxidant-based therapies as main intervention and clinical trials with no reported results were also excluded

Time-sensitive management is therefore the most effective strategy to limit irreversible damage and preserve neuronal integrity [84]

These are the side effects that cause people to abandon treatment entirely

The heterogeneity of study populations and interventions across different trials makes it challenging to draw definitive conclusions about optimal treatment approaches