Despite their therapeutic efficacy, the clinical application of GLP-1 receptor agonists is frequently associated with gastrointestinal complications, including nausea, vomiting, and diarrhea, with rare but serious adverse events such as pancreatitis and cholelithiasis being documented in clinical reports 10,11
This relatively prolonged half-life is a key pharmacological characteristic of the molecule and has important implications for how the drug is administered and how it behaves within the body over time
The risk of metformin accumulation and lactic acidosis increases in proportion to the degree of renal impairment, therefore, the drug should not be prescribed to patients with serum creatinine concentrations above the upper age limit of normal
Then the resulting aberrant sperm showed lower concentration and abnormal morphology, leading to reduced fertility
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