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Microdosing GLP-1 Receptor Agonists During Perimenopause: A Clinical Approach to Hormonal Weight Gain Written and edited by Sarah Bonza MD, MPH, FAAFP, MSCP, DipABLM, NBC-HWC Perimenopause represents a challenging time for women, with up to 70% experiencing weight gain due to declining estrogen levels, decreased energy expenditure, and metabolic changes

Third, the sample sizes of the reported trials were small, which affects the credibility of the results

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through indirect stimulation of dopamine and norepinephrine receptors