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Phase 2 data published in the New England Journal of Medicine in 2023 showed that the 12 mg dose produced a mean 24.2% reduction in body weight at 48 weeks in adults with obesity, which is numerically larger than anything reported for a single agent in a controlled trial to that point

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Additionally, the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and fibroblast growth factor 21 receptor (FG21R) significantly impact these metabolic processes