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More recent studies have shown that regional depletion of glutamine from PDAC tumors stimulates macropinocytosis by activating EGFR/PAK signaling and supplying glutamine via degradation of extracellular proteins in lysosomes 121
10.1038/s41598-018-24661-z 49 DuanH.YangS.YangS.ZengJ.YanZ.ZhangL.et al (2024)
The response is dependent on temperature conditions
Abstract Arsenic (As), naturally occurring metalloid and a potential hazardous material, is found in low concentrations in the environment and emerges from natural sources and anthropogenic activities
J Adv Res 55:4560 Bjrnsson HK, Bjrnsson ES (2022) Drug-induced liver injury: Pathogenesis, epidemiology, clinical features, and practical management
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