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For example, you need to produce data on dosage, route of administration, and more

Understanding Vitamin B12 Deficiency Vitamin B12 deficiency develops when the body cannot adequately absorb or utilize this water-soluble vitamin

This is clinically significant for drugs with narrow therapeutic windows (thyroid hormone, anticoagulants, immunosuppressants)

The transgenic overexpression of HGF in the nervous system attenuates spinal motoneuronal death and axonal degeneration, delays onset of the disease, and prolongs the lifespan of SOD1-G93A mice (Sun et al., 2002)