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Intriguingly, HK2-induced glycolysis boosts histone Kla, especially H3K18la, which facilitates the transcription and expression of HSC activation-induced genes, including -SMA, Col1a1, and Timp1, thereby governing HSC activation and leading to liver fibrosis

Gastrointestinal side effects (nausea, vomiting, diarrhea) occur in 3050% of tirzepatide users during dose titration and typically resolve within 48 weeks

Importantly, Mahsa emphasizes that even with treatment, flares can still trigger severe headaches and that many doctors underestimate their connection to IgG4-RD

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