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Shaw Key Takeaways FDA enforcement will focus on restricting GLP-1 APIs in mass-marketed, nonapproved compounded products to address unverifiable quality, safety, and efficacy under the FD&C Act
34, 35, 36, 37, 38, 39 However, it is unknown if GLP-1R occurs on PSCs in normal pancreas, on activated PSCs in AP or CP or if this does occur, whether the GLP-1R agonists affect the PSC signaling cascade, PSC growth or ability to release inflammatory mediators
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