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These side effects are often mild and tend to decrease over time as the body adjusts to the medication
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Interestingly, weight loss generally reduces GERD severity over time, so while early GI effects of tirzepatide may transiently worsen symptoms, long-term weight reduction might ultimately improve reflux for many patients
However, in our subgroup analysis, when compared to the placebo or basal insulin groups, we observed a statistically significant association between tirzepatide and an increased risk of the composite of gallbladder or biliary diseases (RR1.97, [95% CI] 1.14 to 3.42
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