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The oral option may ultimately be the more transformative contribution, but CagriSema will likely reach the market first

Verdict: Direct comparison difficult due to different trial designs, but retatrutide's advantage appears substantial even accounting for flexible vs fixed dosing

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Their combined treatment synergistically activates the Nrf2/Keap1 pathway, effectively blocking myoglobin-induced ferroptosis

Friederike Vlter, orcid.org/0000-0001-6157-0363 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers