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149 PatelJ
Non-response at standard dosing often indicates either high baseline homocysteine (requiring twice-weekly dosing) or concurrent folate deficiency (impairing methionine-to-SAMe conversion)
Information on protocol deviations as a result of the COVID-19 pandemic is provided in ESM Appendix 2
Off-label uses: In some cases, it may be prescribed for weight management
Rarer serious events reported include pancreatitis, gallbladder disease, and acute kidney injury linked to dehydration
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