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Clinical studies have confirmed that hyperhomocysteinemia is not only an independent risk factor for the development of cardiovascular and cerebrovascular diseases, such as atherosclerosis, acute myocardial infarction, stroke, coronary artery lesions, and peripheral vascular disease, but also increases the risk of neurodegenerative disorders and tumors, and impairs the efficacy of antifolate drugs
[2] [6] Report new or worsening symptoms promptly, including severe abdominal pain (potential pancreatitis), visual changes, chest pain, leg swelling or pain (potential thrombosis), unexplained vaginal bleeding, or persistent gastrointestinal symptoms
Neurology 89 , 11351141 (2017)
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