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GLP-1 is produced naturally by specialized cells in your intestines in response to food intake

J Clin Endocrinol Metab 77: 919, 1993 190 Suda T, Iwashita M, Tozawa F et al: Characterization of corticotrophin-releasing hormone binding protein in human plasma by chemical cross-linking and its binding during pregnancy

2h, leading to a loss of GLP-1R constitutive activity or capacity to respond to locally produced GLP-1 31

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While direct head-to-head comparisons in randomized clinical trials are limited, real-world evidence and observational studies help supplement the lack of direct head-to-head clinical trial data, offering important context for clinical decision-making