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It typically peaks during dose escalation and resolves within 1-2 weeks at each new dose level
In addition to impacting the speed of absorption of oral supplements, the digestive process also affects the extent of absorption, with 40%-50% of low-dose B12 vitamins being absorbable
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Inhibiting an endogenous metabolic enzyme can create effects beyond the intended experimental target, particularly when human exposure and long-term safety have not been established