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We then compared the PK following subcutaneous administration of four treatment regimens: (i) repeated daily 20 g injections of Sema in a saline vehicle to mimic current clinical practice, [48] (ii) single PNP Sema hydrogel formulations, (iii) single PNP TZP hydrogel formulations, and (iv) repeated daily PBS injections as an untreated control (5 n 6 for each treatment group)

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A 2026 systematic review found that GLP-1 receptor agonists were associated with increases in testosterone levels, particularly in people with obesity, type 2 diabetes, or functional hypogonadism

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Genetic variation in GLP-1 receptor (GLP1R), glucagon-dependent insulinotropic polypeptide receptor (GIPR), and melanocortin-4 receptor (MC4R) pathways may influence individual metabolic response and side-effect tolerance