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Studies have shown that Erastin can also modulate p53 signaling outside its canonical ferroptosis activity, altering transcriptional programs that regulate cell-cycle progression and stress responses and thereby intensifying cytotoxicity in sensitive tissues (96)

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BMC Syst Biol 7:103 Liu B, Teschemacher AG, Kasparov S (2017) Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders

Lindholm et al., 1989

It is thought that early induction of these antioxidative systems should significantly contribute to the protective mechanism of proline supplementation in this model